Neuroprotection by Hyperbaric Oxygenation After Experimental Focal Cerebral Ischemia
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چکیده
Nils Henninger, Harald Müller, Ulrich Carl, Shinya Toyokuni, Clemens Sommer and Stefan Wolf-Ruediger Schäbitz, Holger Schade, Sabine Heiland, Rainer Kollmar, Jürgen Bardutzky, Monitored by MRI Neuroprotection by Hyperbaric Oxygenation After Experimental Focal Cerebral Ischemia Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.0000125868.86298.8e 2004;35:1175-1179; originally published online April 1, 2004; Stroke. http://stroke.ahajournals.org/content/35/5/1175 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI.
BACKGROUND Hyperbaric oxygenation (HBO) after focal cerebral ischemia reduces infarct size and improves outcome when applied early after stroke. Here, we evaluated effects of HBO on permanent focal cerebral ischemia and applied magnetic resonance imaging (MRI) monitoring to study lesion evolution. METHODS Rats underwent permanent middle cerebral artery occlusion (MCAO). Two hours later, anima...
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The neuroprotective effect of oxygen after acute stroke in rats has been shown previously. However, the question of optimal dosing still remains unanswered. Thus, we investigated the use of oxygen at different concentrations by either normobaric oxygenation (NBO) or hyperbaric oxygenation (HBO) at different pressures in a model of transient ischemia/reperfusion in rats. Animals underwent 90 min...
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OBJECTIVE Both, second generation perfluorochemicals (Oxycyte®) and hyperbaric oxygen (HBO) have been shown to reduce necrotic tissue volume if administered early after experimental cerebral ischemia. With the idea of exponentiation of oxygen delivery to ischemic tissue, this study was conducted to investigate the combined effect of both treatment modalities on the extent of ischemic brain dama...
متن کاملMechanisms of hyperbaric oxygen and neuroprotection in stroke.
Cerebral vascular diseases, such as neonatal encephalopathy and focal or global cerebral ischemia, all result in reduction of blood flow to the affected regions, and cause hypoxia-ischemia, disorder of energy metabolism, activation of pathogenic cascades, and eventual cell death. Due to a narrow therapeutic window for neuroprotection, few effective therapies are available, and prognosis for pat...
متن کاملHyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest.
BACKGROUND AND PURPOSE Studies suggest that hyperbaric oxygen (HBO) is neuroprotective after experimental cerebral ischemia, but the mechanism is unknown. This study tested the hypotheses that postischemic HBO affords clinical and histopathological neuroprotection after experimental cardiac arrest and resuscitation (A/R) and that this neuroprotection results from improved cerebral oxygen metabo...
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تاریخ انتشار 2004